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Backup quarterback Trey Lance knee and defensive tackles Javon Kinlaw knee and Maurice Hurst calf have all been ruled out. Starting left tackle Trent Williams is listed as doubtful because of elbow and ankle injuries. He zinged it a little bit in practice on Monday and he hasn't been able to go since. For Trent, of anybody on this team, we'll take it all the way up to game time. While Garoppolo is back in the mix, Lance, who filled in for Garoppolo in a Week 5 loss to Arizona, will not be available against Indianapolis.

Lance is dealing with a sprained left knee and did not practice all week, though the Niners are hopeful he'll be back next week. Veteran Nate Sudfeld will again be elevated from the practice squad to serve as Garoppolo's backup. Garoppolo suffered the calf injury early in an Oct. After that game, Garoppolo quickly self-diagnosed the injury, saying he hoped it would be only a couple of weeks.

That turned out to be accurate, as Garoppolo missed only the Arizona game because the Niners had a Week 6 bye. So, it was I just kind of knew my body and knew it was going to take a couple of weeks.

It was just a little pull. It wasn't anything too serious. As he worked his way back from the injury, Garoppolo stayed near the team facility, rehabbing with an eye toward playing against Indianapolis.

The Niners invested heavily in Lance this offseason, trading three first-round picks to take him third overall in the draft to be quarterback of the future. San Francisco wanted to be patient with Lance, who had only one season as a starter in college at lower-level North Dakota State. Lance played just seven snaps in a situational role the first three weeks before playing the entire second half in last week's loss to Seattle.

Now he gets his first chance to start when he will try to become the first Niners rookie quarterback to win his first start since Jim Druckenmiller won his only career start in You try to prepare a guy as good as you can from our standpoint.

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